The Group

Using cellular model systems and in vivo mouse models we try to understand neuropsychiatric disease risk from novel angles. We are particularly interested in risk factors that affect neuroendocrine signaling and that can have long lasting consequences on the brain, the germline and the offspring. We study how stress shapes the chromatin and it’s epigenetic signature in sperm cells, and how this is important to the developing embryo and a trajectory that increases predisposition to disease. On a technical level this requires a broad range of experimental approaches including assisted reproductive techniques, several omic sequencing, behavioral and metabolic phenotyping. We also develop and employ new tools to dissect the molecular basis of gene regulation such as CrispR and PROTACs.